Dr, Robert Floyd
My Wife had Stage 3 Hodgkin's Lymphoma September 2005 and was treated with ABVD over 8 months and following PET Scan was negative for 4 yrs. and 8 months, when she noticed a swelling in the right posterior neck that resulted in her seeing her PCMD who referred her to a surgeon who did an excisonal biopsy of the lymph node which was read as Atypical Lymphoid Hyperplasia I requested a second opinion and the material was sent Stanford University and after 8 weeks a report of Angioimmunoblastic T-Cell Lymphoma was made and the PET scan showed hypermetabolic lesions in the right posterior cervical region and the left common Iliac nodes which made it a Stage 3.
All of her Liver,spleen, Bone Marrow was negative and Lab. work was normal except the platlet count had fallen from 404,000 to 132,000 and ske had predominence of monocytes in the blood smear, and she began to feel fatiged.
She was started on CHOP chemotherapy for 4-6 courses,
although the FDA had appproved Fotolyn (pralatrexate)
for a new treatment for Peripheral T Cell Lymphoma (PTCL) She will start her second course on 16th of June.
Dr Robert:
I hope your wife is responding to the CHOP therapy. You mentioned pralatrexate as a possible chemo agent but while CHOP's success rate in T-cell lymphomas isn't as great as we all might hope, pralatrexate has only been approved for relapsed or refractory PTCL, and furthermore, I think the primary reason it was approved at all was because of the ODOC's fondness for filling gaps, and there was no other approved treatment for relapsed PTCL. otherwise, pralatrexate performed miserably in phase III trials, generating a response- mostly partial response- in just 27% of the cohort. I don't remember what the % was for CR, but I do recall it being very small.
At any rate, I do hope for the best for your wife.
Ross
Dr Roberts
I hope your wife is doing much better wishing for the best.
Mill
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Dr. F
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